mdCATH: A Large-Scale MD Dataset for Data-Driven Computational Biophysics

mdCATH: A Large-Scale MD Dataset for Data-Driven Computational Biophysics

mdCATH: A Large-Scale MD Dataset for Data-Driven Computational Biophysics

mdCATH: A Large-Scale MD Dataset for Data-Driven Computational Biophysics

mdCATH: A Large-Scale MD Dataset for Data-Driven Computational Biophysics

mdCATH: A Large-Scale MD Dataset for Data-Driven Computational Biophysics

mdCATH: A Large-Scale MD Dataset for Data-Driven Computational Biophysics

mdCATH: A Large-Scale MD Dataset for Data-Driven Computational Biophysics

mdCATH: A Large-Scale MD Dataset for Data-Driven Computational Biophysics

mdCATH: A Large-Scale MD Dataset for Data-Driven Computational Biophysics

Mutations in the DNA methyltransferase 1 (DNMT1) gene can lead to neurodegenerative diseases, including autosomal dominant cerebellar ataxia-deafness and neuropathy (ADCA-DN) and hereditary sensory and autonomic neuropathy type 1E (HSAN1E). This project presents four independent, all-atom, two-microsecond molecular dynamics (MD) simulations of wild-type DNMT1 and three ADCA-DN variants, as well as two HSAN1E variants.

Mutations in the DNA methyltransferase 1 (DNMT1) gene can lead to neurodegenerative diseases, including autosomal dominant cerebellar ataxia-deafness and neuropathy (ADCA-DN) and hereditary sensory and autonomic neuropathy type 1E (HSAN1E). This project presents four independent, all-atom, two-microsecond molecular dynamics (MD) simulations of wild-type DNMT1 and three ADCA-DN variants, as well as two HSAN1E variants.

The all-atom molecular dynamics (MD) simulation trajectory of dedicator of cytokinesis 7 (DOCK7; 1000 ns).

The all-atom molecular dynamics (MD) simulation trajectory of DNA methyltransferase 1 (DNMT1; 400 ns) and dedicator of cytokinesis 7 (DOCK7; 1000 ns).

Mutations in the DNA methyltransferase 1 (DNMT1) gene can lead to neurodegenerative diseases, including autosomal dominant cerebellar ataxia-deafness and neuropathy (ADCA-DN) and hereditary sensory and autonomic neuropathy type 1E (HSAN1E). This project presents four independent, all-atom, two-microsecond molecular dynamics (MD) simulations of wild-type DNMT1 and three ADCA-DN variants, as well as two HSAN1E variants.

Mutations in the DNA methyltransferase 1 (DNMT1) gene can lead to neurodegenerative diseases, including autosomal dominant cerebellar ataxia-deafness and neuropathy (ADCA-DN) and hereditary sensory and autonomic neuropathy type 1E (HSAN1E). This project presents four independent, all-atom, two-microsecond molecular dynamics (MD) simulations of wild-type DNMT1 and three ADCA-DN variants, as well as two HSAN1E variants.

Mutations in the DNA methyltransferase 1 (DNMT1) gene can lead to neurodegenerative diseases, including autosomal dominant cerebellar ataxia-deafness and neuropathy (ADCA-DN) and hereditary sensory and autonomic neuropathy type 1E (HSAN1E). This project presents four independent, all-atom, two-microsecond molecular dynamics (MD) simulations of wild-type DNMT1 and three ADCA-DN variants, as well as two HSAN1E variants.

Mutations in the DNA methyltransferase 1 (DNMT1) gene can lead to neurodegenerative diseases, including autosomal dominant cerebellar ataxia-deafness and neuropathy (ADCA-DN) and hereditary sensory and autonomic neuropathy type 1E (HSAN1E). This project presents four independent, all-atom, two-microsecond molecular dynamics (MD) simulations of wild-type DNMT1 and three ADCA-DN variants, as well as two HSAN1E variants.